AJT Highlights

AJT December 2025 Editors’ Picks

AJT December 2025 Editors’ Picks

Description:  Hosts Roz and Dr. Sanchez-Fueyo are joined by Hannah Bahakel to discuss the key articles of the December issue of the American Journal of Transplantation.

Hannah Bahakel is a Clinical Immunodeficiency fellow at Cincinnati Children’s Hospital Medical Center

[03:34] Higher vs standard mean arterial pressure target in the immediate postoperative period of liver transplantation to prevent acute kidney injury: A randomized clinical trial (LIVER-PAM)

[13:51] Donor-derived cell-free DNA significantly improves rejection yield in kidney transplant biopsies

[26:27] Tolerogenic lung allograft microenvironment suppresses pathogenic tissue remodeling following respiratory virus infection in mice

[37:11] Therapeutic needs in solid organ transplant recipients: The American Society of Transplantation patient survey

[48:19] Impact of kidney function on 200 days of antiviral prophylaxis for cytomegalovirus disease in cytomegalovirus-seronegative recipients of cytomegalovirus-seropositive donor kidneys: Post hoc analysis of a randomized, phase 3 trial of letermovir vs valganciclovir prophylaxis

AJT November 2025 Editors’ Picks

Description:  Hosts Roz and Dr. Sanchez-Fueyo are joined by Christie Rampersad to discuss the key articles of the November issue of the American Journal of Transplantation.

Christie Rampersad is clinical associate, in the Division of Nephrology at the University of Toronto in the Ajmera Transplant Centre

[03:45] The early impacts of an attempt to standardize kidney procurement biopsy practices

[13:40] The current state of simultaneous heart-liver transplantation in the United States

[20:11] Engaging patients in organ transplant listing meetings: A survey study

[37:32] Single-cell transcriptional landscape of liver transplant rejection reveals tissue persistence of clonally expanded, treatment-resistant T cells

[45:32] Infectious disease surveillance and management in clinical xenotransplantation: Experience with the first human porcine kidney transplant

AJT October 2025 Editors’ Picks

AJT October 2025 Editors’ Picks

Description:  Hosts Roz and Dr. Sanchez-Fueyo are joined by Dr. Christina Haugen to discuss the key articles of the October issue of the American Journal of Transplantation.

Dr. Christina Haugen is an Assistant Professor of Surgery at the University of Cincinnati.

[03:28] Renal resistance trajectories during hypothermic machine perfusion in kidneys donated after circulatory death: Associations with donor characteristics and posttransplant outcomes—An analysis of COMPARE trial data

[10:26] Donor-specific mesenchymal stem cell infusion in human and nonhuman primate kidney transplantation

[19:21] Potential targeting of urokinase-type plasminogen activator receptor–formyl peptide receptor signaling to prevent recurrence in posttransplant primary podocytopathies

[30:20] The relationship between cessation of brain and systemic circulation after withdrawal of life-sustaining measures

[36:03] Pretransplant natural antibody levels identify a subset of deceased donor kidney transplant recipients that benefit from infliximab induction

AJT September 2025 Editors’ Picks

Hosts Roz and Dr. Sanchez-Fueyo discuss the key articles of the September issue of the American Journal of Transplantation.

[03:30] Blunted cardiac reserve as a marker of cirrhotic cardiomyopathy—Cardiac outcomes following liver transplantation and comparison to the existing guidelines

[14:18] Back-table intra-arterial administration of C1 esterase inhibitor to deceased donor kidney allografts improves posttransplant allograft function: Results of a randomized double-blind placebo-controlled clinical trial

[25:55] Donor-derived cell-free DNA is associated with the degree of immunosuppression in lung transplantation

[36:24] A two-threshold algorithm using donor-derived cell-free DNA fraction and quantity to detect acute rejection after heart transplantation

[45:00] Cell therapy with human Interleukin 10–producing ILC2s enhances islet function and inhibits allograft rejection

Kidney transplantation for undocumented immigrants in the United States: challenges and Ethical considerations

In this Specialty Podcast, Dr. Dami Ko is joined by Dr. Katherine Rizzolo, and Dr. Leonela Villegas to discuss kidney transplantation for undocumented immigrants in the United States, particularly the challenges they face and ethical considerations.

Dr. Dami Ko is an assistant professor at Northeastern University, specializing in post-transplant care and quality of life.

Dr. Katherine Rizzolo is a nephrologist in Boston, MA.

Dr. Leonela Villegas is a Pediatric Nephrologist at Hartford, CT

References:

Long-term impact of immigration status on outcomes in pediatric kidney transplant recipients. 

Successful pathways to liver transplant for undocumented immigrants. 

Undocumented immigrants: A glaring inequity in transplant.

AJT August 2025 Editors’ Picks

Hosts Roz and Alberto are joined by new Editorial Fellow Dr. Sofia Bin to discuss the key articles of the August issue of the American Journal of Transplantation.

Dr. Sofia Bin is an assistant professor of medical and surgical sciences at the University of Bologna.

 

[02:46] Gut microbiome alterations precede graft rejection in kidney transplantation patients

[10:31] Molecular diagnosis of kidney allograft rejection based on the Banff Human Organ Transplant gene panel: a multicenter international study

Editorial: Graft biopsy reimagined: Integrating morphology and molecular maps

[22:20] Does a changing donor pool explain the recent rise in the United States kidney nonuse rate?

[32:45] A scintigraphic look at the dead donor rule in donation after the circulatory determination of death with the use of normothermic regional perfusion: A single-center interventional trial

Editorial: Normothermic regional perfusion in donation after circulatory determination of death—Confirming the absence of brain reperfusion

[37:03] Global variation in living donor liver transplantation practices impacts donor and recipient short-term outcomes: initial insights from the International LDLT Registry

AJT July 2025 Editors’ Picks

Hosts Roz and Alberto discuss the key articles of the July issue of the American Journal of Transplantation.

[03:48] Liver transplantation for hepatitis D virus/hepatitis B virus coinfection in Italy: an intention-to-treat analysis of long-term outcomes

[13:42] 10 degree C static storage of porcine donation after circulatory death livers improves biliary viability and mitigates ischemia-reperfusion injury

[22:20] Fewer medullary pyramids in the living kidney donor are associated with graft failure in the recipient

[33:35] Microvascular inflammation in kidney allografts: New directions for patient management

MOMOT (Mouse Models in Transplant) articles:

Can mouse kidney transplant models inform mechanisms of injury and acceptance in clinical kidney transplantation?

Best practices in islet transplantation in mice

AJT June 2025 Editors’ Picks

Host Roz is joined by new co-host Alberto Sanchez-Fueyo, MD, PhD to discuss the key articles of the June issue of the American Journal of Transplantation.

Dr. Sanchez-Fueyo is a Professor of Hepatology, and the Academic Director of the Institute of Liver Studies, King's College, London.

[02:51] Recipient toll-like receptor 4 determines the outcome of ischemia-reperfusion injury in steatotic liver transplantation in mice

[10:47] Association between everolimus combination therapy and cancer risk after liver transplantation: A nationwide population-based quasi-cohort study

[21:35] Balancing equity and human leukocyte antigen matching in deceased-donor kidney allocation with eplet mismatch

Editorial: Equitable allocation through human leukocyte antigen eplet matching: A promising strategy with several challenges

[32:51] Impact of the lung allocation system score modification by blood type on US lung transplant candidates

Editorial: From flawed to fairer: Reducing blood type bias in lung transplant allocation

Recommended article: The economic value of a transplant nephrologist: The case for improving compensation models

Overcoming Barriers: Revitalizing Pancreas Transplantation in the U.S.

In this specialty podcast, Dr. Alissar El Chediak is joined by Dr. Jon Odorico and Dr. Ron Parsons to discuss the current state of pancreas transplantation, identify barriers and strategies for referral and candidate selection, and discuss solutions to address the decline in procedures.

Alissar El Chediak, MD is a transplant nephrologist at UT Southwestern Medical Center.

Jon Odorico, MD is a transplant surgeon at the University of Wisconsin.

Ron Parsons, MD is a transplant surgeon at the University of Pennsylvania.

 

References:

Generating strategies for a national comeback in pancreas transplantation: A Delphi survey and US conference report

Bird Flu and Transplant Patients: Emerging Risks and Clinical Insights

In this Specialty Podcast, Dr. Alejandra Mendoza is joined by Dr. Cameron Wolfe, infectious diseases specialist at Duke University, to discuss the growing concern of avian influenza (H5N1) in transplant recipients. Together, they explore the latest epidemiologic developments, potential risks to immunocompromised patients, and key considerations for clinicians managing solid organ and stem cell transplant recipients in the face of this evolving threat.

Dr. Alejandra Mendoza is a transplant infectious diseases physician at the University of Utah. Dr. Cameron Wolfe is a professor of medicine in the division of infectious diseases at Duke University.

References:

Clinician Update on Human Cases of H5N1 and Influenza A Virus Surveillance (COCA Calls)