AJT Highlights

AJT November 2023 Editors’ Picks

Host Roz is joined by Ramsey Hachem, MD (Washington University School of Medicine in Saint Louis) and AJT Editorial Fellow Helen Tsai, MD (Montefiore Medical Center) 

[03:30] Disseminated vaccine-induced varicella infection in a kidney transplant recipient

[06:50] Safety and Immunogenicity of the Live-Attenuated Varicella Vaccine in Pediatric Solid Organ Transplant Recipients: A Systematic Review and Meta-Analysis

[10:34] (Editorial) Balancing the live virus vaccine scales: protection vs risk

[14:22] Outcomes after flow cytometry crossmatch-positive lung transplants managed with perioperative desensitization

[19:25] Lung transplantation despite preformed donor-specific anti-HLA antibodies: 9-year single-center experience

[23:00] (Editorial) What is a Clinically Significant Donor-Specific Antibody Before Lung Transplantation?

[25:38] Deceased Donor Kidneys from Higher Distressed Communities are Significantly Less Likely to be Utilized for Transplantation

[35:11] (Editorial) Understanding the mechanisms and implications of the association between community distress and organ non-utilization

[37:18] Sex as a Biological Variable: Mechanistic Insights and Clinical Relevance in Solid Organ Transplantation

AJT October 2023 Editors’ Picks

Host Roz is joined by AJT Editorial Fellow Salil Kumar, MD (incoming Assistant Professor at MD Anderson Medical Center)

[2:24] Importance of social vulnerability on long-term outcomes after heart transplantation

[12:51] Microbiota-dependent and -independent effects of obesity on transplant rejection and hyperglycemia

[21:26] Memory T follicular helper cells drive donor-specific antibodies independent of memory B cells and primary germinal center and alloantibody formation

[28:52] Validation of a prediction system for risk of kidney allograft failure in pediatric kidney transplant recipients: An international observational study

[36:44] Qualifying a novel clinical trial endpoint (iBOX) predictive of long-term kidney transplant outcomes

AJT September 2023 Editors’ Picks

Host Roz is joined by AJT Editorial Board Member Kenneth Newell, MD, PhD (Emory University) and AJT Editorial Fellow Kyle Jackson, MD, PhD (Emory University)

[2:45] Identifying and understanding variation in population-based access to liver transplantation in the United States

[12:44] Intra-graft B cell differentiation during the development of tolerance to kidney allografts is associated with a regulatory B cell signature revealed by single cell transcriptomics

[18:21] Single-cell RNA sequencing reveals peripheral blood mononuclear immune cell landscape associated with operational tolerance in a kidney transplant recipient

[22:20] Impact of allele-specific anti-HLA class I antibodies on organ allocation

[28:12] Autoantibodies against DNA-topoisomerase I promote renal allograft rejection by increasing alloreactive T cell responses

Ethical Issues Related to Informed Consent and Informed Authorization for Xenotransplantation

In this specialty podcast, Carrie Thiessen, MD, PhD (University of Wisconsin-Madison) hosts Robert Montgomery, MD, PhD, (NYU Langone) and Muhammad Mohiuddin, MBBS, (University of Maryland) to discuss ethical issues related to informed authorization and informed consent for decedent kidney and human cardiac xenotransplants.

AJT August 2023 Editors’ Picks

Host Roz is joined by AJT Editorial Board Member Sanjay Kulkarni, MD, (Yale School of Medicine) and AJT Editorial Fellow Luise Holzhauser, MD (University of Pennsylvania)

[2:40] In a real-life setting, risk factors, Coronary artery calcium score and coronary stenosis at Computed Tomography Angiography are associated with MACE and all-cause mortality among kidney transplant candidates

[16:00] The minimum weight and age of kidney donors: En bloc kidney transplantation from preterm neonatal donors weighing less than 1.2kg to adult recipients

[24:35] Increased volume of organ offers and decreased efficiency of kidney placement under circle-based kidney allocation

[31:07] Recipient Race Modifies the Association between Obesity and Long-term Graft Outcomes After Kidney Transplantation

International efforts to eliminate gender disparities in allocation of liver transplants: MELD 3.0 & Gender-Equity Model for Liver Allocation (GEMA)

In this AJT specialty podcast, Aly Strauss, hosts Allison Kwong and Manuel Rodriguez-Peralvarez to discuss MELD 3.0,  Gender-Equity Model for Liver Allocation (GEMA), and international efforts to eliminate gender disparities in allocation of liver transplants. 

 

Bernards et al. AJT: https://pubmed.ncbi.nlm.nih.gov/35871752/

 

Kim et al. Meld 3.0: https://pubmed.ncbi.nlm.nih.gov/34481845/

Meld 3.0 calculator: https://medcalculators.stanford.edu/meld

 

Rodriguez-Peralvarez et al. GEMA: https://pubmed.ncbi.nlm.nih.gov/36528041/

GEMA calculator: http://gema-transplant.com/

AJT July 2023 Editors’ Picks

Host Roz is joined by AJT Editorial Board Member Seth Karp, MD (Vanderbilt University Medical Center) and AJT Editorial Fellow Thiago Borges, PhD (Massachusetts General Hospital)

[2:33] Xenorecognition and costimulation of porcine endothelium-derived extracellular vesicles in initiating human porcine-specific T cell immune responses

[11:28] The tele-liver frailty index (TeLeFI): development of a novel frailty tool in patients with cirrhosis via telemedicine

[21:18] The 20-year paradigm shift toward organ recovery centers: 2500 donors at Mid-America Transplant and broader adoption across the United States

[33:13] Outcomes of lung and liver transplantation after simultaneous recovery using abdominal normothermic regional perfusion in donors after the circulatory determination of death versus donors after brain death

[42:17] Stakeholders’ perspectives on transplant metrics: the 2022 Scientific Registry of Transplant Recipients’ consensus conference

AJT June 2023 Editors’ Picks

Hosts Roz and Josh discuss the key articles of the June issue of American Journal of Transplantation.

[1:30] The evolving use of biomarkers in heart transplantation: Consensus of an expert panel

[9:49] Effects of in vivo CXCR4 Blockade and Proteasome Inhibition on Bone Marrow Plasma Cells in HLA Sensitized Kidney Transplant Candidates

[16:50] An ethical analysis of obesity as a contraindication to pediatric liver transplant candidacy

[23:53] Racial and ethnic disparities in psychosocial evaluation and liver transplant waitlisting

AJT May 2023 Editors’ Picks

Host Roz and Josh are joined by AJT Editorial Fellow Scott Krummey, MD, PhD, to discuss the key articles of the May issue of American Journal of Transplantation.

 

[01:59] Genetic evaluation of living kidney donor candidates: A review and recommendations for best practices

 

[11:36] Mutations In Latent Membrane Protein 1 of Epstein-Barr Virus are Associated with Increased Risk for Post-Transplant Lymphoproliferative Disorder in Children

 

[23:13] Impacts of removing race from the calculation of the Kidney Donor Profile Index

 

[31:49] The Association of Donor Hepatitis C Virus Infection with Three-Year Kidney Transplant Outcomes in the Era of Direct-Acting Antiviral Medications

 

[41:40] Time to discard the term “discard”

 

AJT April 2023 Editors’ Picks

Host Roz and Josh are joined by AJT Editorial Fellow Daniel Galvez Lima, MD, to discuss the key articles of the April issue of American Journal of Transplantation.

[02:01] Successful pathways to liver transplant for undocumented immigrants, Kerznerman et al

[10:30] Effect of vitamin K supplementation on serum calcification propensity and arterial stiffness in vitamin K-deficient kidney transplant recipients: A double-blind, randomized, placebo-controlled clinical trial, Eelderink et al

[18:07] ABO Genotyping finds more A2 to B kidney transplant opportunities than lectin-based subtyping, Joseph et al

[29:15] Oxidative stress and related metabolic alterations are induced in ex situ perfusion of donated hearts regardless of the ventricular load or leukocyte depletion, Hatami et al